Protein Details: Transient receptor potential channel mucolipin 2

Protein ID

ICDB_Pro_1258

Protein Name

Transient receptor potential channel mucolipin 2

Gene Name

MCOLN2

Organism

Homo sapiens (Human)

Length

566 amino acids

AlphaFoldDB

AF-Q8IZK6-F1-model_v4.pdb

Function

Sequence

MARQPYRFPQARIPERGSGVFRLTVRNAMAHRDSEMKEECLREDLKFYFMSPCEKYRARRQIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETLNIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSRELPDCYVFQNTIIFDNKAHSGKIKIYFDSDAKIEECKDLNIFGSTQKNAQYVLVFDAFVIVICLASLILCTRSIVLALRLRKRFLNFFLEKYKRPVCDTDQWEFINGWYVLVIISDLMTIIGSILKMEIKAKNLTNYDLCSIFLGTSTLLVWVGVIRYLGYFQAYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHDKFENLNTVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQQNGFPETDLQEFLKECSSKEEYQKESSAFLSCICCRRRKRSDDHLIPIS

PDB Structures

6HRR 6HRS

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Autosomal Recessive Nonsyndromic Deafness 107 and Spinocerebellar Ataxia;Autosomal Recessive 26

Location

DOI ID

10.1073/pnas.222425399; 10.1038/nature04727; 10.1101/gr.2596504; 10.1038/ng1285; 10.1111/j.1600-0854.2007.00619.x; 10.1074/jbc.m109.046508; 10.1002/jcp.21956; 10.1111/tra.12205

RefSeq

NP_001317576.1 [Q8IZK6-2]; NP_694991.2 [Q8IZK6-1]; XP_005270776.1 [Q8IZK6-2]; XP_011539489.1 [Q8IZK6-2]; XP_011539490.1 [Q8IZK6-2];